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Table 1 Association analysis of TREM2 variant c.140G>A (rs75932628; p.R47H) in disease

From: TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Disorder (n)

Patient, n(%)

Control, n(%)

OR (95% CI)

p-valuea

Controls

(1324)

  

6

(0.45)

   

FTD

(609)

13

(2.1)

6

(0.45)

5.064

(1.9, 13.51)

0.0012

ALS

(765)

5

(0.7)

6

(0.45)

1.466

(0.43, 4.94)

0.5378

PD

(683)

9

(1.3)

6

(0.45)

3.144

(1.1, 9.03)

0.0333

PSP

(722)

5

(0.6)

6

(0.45)

1.537

(0.41, 5.78)

0.5249

Ischemic Stroke

(448)

3

(0.7)

6

(0.45)

1.506

(0.37, 6.17)

0.5689

  1. a Uncorrected p-values are shown. The association in FTD would remain significant after a conservative Bonferroni correction for multiple testing (significance level p<0.01).
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Molecular Neurodegeneration

ISSN: 1750-1326