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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

Fig. 6

APN enhanced neuronal insulin sensitivity in vitro. a AdipoR1 and AdipoR2 expressions in SH-SY5YswAPP cells upon RNAi transfection. b Representative image of pAMPK levels upon APN treatment in SH-SY5YswAPP cells transfected with scrambled, AdipoR1 or AdipoR2 RNAi duplex. c Representative images of western blot of pAkt, Akt, pGSK3βS9 and GSK3β in SH-SY5YswAPP cells transfected with scrambled, AdipoR1 or AdipoR2 RNAi duplex that cultured with/without 10 nmol/L insulin, APN or with 10 μg/mL trimeric APN (APNTri) & 10 nmol/L insulin. d Levels of extracellular Aβ42 upon APN treatment in SH-SY5YswAPP cells transfected with scrambled, AdipoR1 or AdipoR2 RNAi duplex. Mean ± S.E.M.; *p < 0.05, **p < 0.01, ***p < 0.001, n.s. statistically not significant

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Molecular Neurodegeneration

ISSN: 1750-1326