Table 1 Standard Transgenic Lines for APP, APP + PS1, and Tau
From: Practical considerations for choosing a mouse model of Alzheimer’s disease
Model | Transgene | Transgenic promoter | Availability | Reference |
|---|---|---|---|---|
APP Transgenics | ||||
PDAPP | huAPP770 (Ind) minigene (cDNA + introns 6–8) | PDGFB | Novartis | [2] |
Tg2576 | huAPP695 (Swe) | hamster Prnp | Taconic, Charles River | [95] |
C3–3 | mo/huAPP695 (Swe) | mouse Prnp | MMRRC 34828-JAX | [96] |
APP23 | huAPP751 (Swe) | mouse Thy1 | JAX 030504 | [100] |
J20 | huAPP770 (Swe/Ind) minigene (cDNA + introns 6–8) | PDGFB | MMRRC 34836-JAX | [54] |
TgCRND8 | huAPP695 (Swe/Ind) | hamster Prnp | Peter St. George-Hyslop | [51] |
Tg-SwDI | huAPP770 (Swe/Dutch/Iowa) | mouse Thy1 | MMRRC 34843-JAX | [210] |
APP/PS1 Transgenics | ||||
APP/PS1 Line 85 | mo/huAPP695 (Swe); Tg huPSEN1 (ΔE9) | mouse Prnp | MMRRC 34832-JAX, 34,829-JAX | [99] |
APPPS1 | huAPP695 (Swe); huPSEN1 (L166P) | mouse Thy1 | Mathias Jucker | [211] |
5XFAD Tg6799 | huAPP695 (Swe/Flo/Lon); huPSEN1 (M146 L/L286 V) | mouse Thy1.2 | MMRRC 34840-JAX, 34,848-JAX | [47] |
Tau Transgenics | ||||
Tau Tg Line 43 | huMAPT3R0N (wt) | mouse Prnp | JAX 003741 | [212] |
JNPL3 | huMAPT4R0N (P301L) | mouse Prnp | Taconic | [34] |
hTau.P301S | huMAPT4R0N (P301S) | mouse Thy1.2 | Michel Goedert | [213] |
PS19 | huMAPT4R1N (P301S) | mouse Prnp | JAX 008169 | [33] |
APP/PS1/Tau Transgenic | ||||
3xTg-AD | huAPP695 (Swe); MAPT4R0N (P301L); Psen1 M146V knock-in | mouse Thy1.2 | MMRRC 34830-JAX | [101] |