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Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Fig. 10

A cohesive model of homeostatic and distinct pro- and anti-inflammatory subsets of DAM in neurodegeneration. Transcriptional regulators, cell surface markers and key drug targets are shown. Each dot in this figure represents a single gene. Colors represent module membership (Blue: Homeostatic module, Red and Midnightblue: M1-like modules not associated with AD, Cyan: M2-like module not associated with AD, Black: intermediate stages, Yellow: anti-inflammatory DAM module upregulated in AD, Magenta: pro-inflammatory DAM module upregulated in AD). Upward and downward arrows indicate direction of change in gene/protein expression. Double arrow (for CD45) indicates higher degree of change in pro-inflammatory DAM as compared to anti-inflammatory DAM subsets

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Molecular Neurodegeneration

ISSN: 1750-1326