Non-carriers (n = 984) | p.R62H (n = 20) | p.R47H (n = 7) | p.L211P (n = 11) | p.D87N (n = 3) | p.R62H/D87N (n = 1) | p.H157Y (n =1) | |
---|---|---|---|---|---|---|---|
Age, y | 73.1 (7.35) | 74.7 (6.47) | 73.5 (11.3) | 72.8 (4.36) | 72.7 (6.17) | 66.4 | 73.1 |
Female, n (%) | 430 (43.7) | 11 (55.0) | 3 (42.9) | 6 (54.5) | 0 | 0 | 1 |
APOE ε4 carriers, n (%) | 467 (47.5) | 8 (40.0) | 5 (71.4) | 2 (18.2) | 2 (66.7) | 0 | 0 |
Education, y | 16.0 (2.78) | 15.7 (2.39) | 15.6 (2.07) | 14.6 (2.54) | 17.0 (2.65) | 15.0 | 18.0 |
CSF biomarkers (pg/ml) | |||||||
T-tau | 289 (136) | 322 (140) | 353 (125) | 231 (119) | 299 (100) | 116 | 214 |
P-tau181P | 27.9 (14.9) | 30.9 (15.6) | 36.4 (15.8) | 22.2 (12.7) | 27.9 (11.5) | 9.92 | 18.1 |
Aβ1-42 | 982 (457) | 1073 (437) | 874 (454) | 1246 (515) | 944 (670) | 925 | 1700 |
sTREM2 | 4136 (2171) | 3418 (1786) | 8790 (6136) | 2386 (1390) | 1981 (244) | 518 | 5642 |
Associated diseases | na | AD | AD, FTD, PD, ALS | AD, FTD | AD | AD | AD |
References | na | [7] | [56] |