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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Fig. 1

Expression of LOAD associated genes in mice. a Expression of AD associated risk genes in LOAD-relevant mice and the APP/PS1 transgenic model compared to B6 (control) mice. X-axis shows AD-associated risk genes and Y-axis represents average log fold change expression of above genes in genetically perturbed mice compare to controls. b Principal component analysis of batch corrected RNA-seq data from mouse strains. The APOEε4 (red circle) and Apoe KO (green circle) samples are most similar to each other. Samples from mice carrying only one copy of either Bin1 (magenta circle) or Cd2ap (orange circle) occupy similar regions, which might be due to their related functions. APP/PS1 samples (brown circle) were separated from mice with late-onset perturbations by the first PC

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Molecular Neurodegeneration

ISSN: 1750-1326